Mouse Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Protein

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Mouse Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein PTPRN2

proveedor

Abbexa

reference

abx650367

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse PTPRN2 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

PTPRN2, also known as IA-2β or phogrin, is closely related to PTPRN and is predominantly expressed in neuroendocrine and neuronal tissues. Like PTPRN, PTPRN2 has a transmembrane region and an intracellular domain with a catalytically inactive phosphatase-like region. PTPRN2 plays a crucial role in insulin and neurotransmitter secretion by regulating secretory granule biogenesis, transport, and exocytosis. It is particularly involved in maintaining the structural integrity of granules and their exocytotic machinery. PTPRN2 is an autoantigen in type 1 diabetes, contributing to β-cell autoimmunity and destruction. It has also been implicated in neurological functions, including synaptic vesicle release and neurotransmitter regulation. Dysregulation of PTPRN2 has been associated with metabolic diseases and neuropsychiatric disorders, highlighting its significance in endocrine and neuronal cell function.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 28.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly782-Gln1001 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

PTPRN2


dry ice

No


availability

Shipped within 5-7 working days.


alias

IAR,ICAAR,PTPRP,IA-2beta,R-PTP-N2,Phogrin,Islet cell autoantigen-related protein,Receptor-type tyrosine-protein phosphatase N2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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