Mouse Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Protein

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
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247€ (10 µg)

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935106861
info@markelab.com
name
Mouse Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650367
tested applications
WB, SDS-PAGE

Description

Mouse PTPRN2 Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Gly782-Gln1001
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 28.7 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P80560
Alias
IAR,ICAAR,PTPRP,IA-2beta,R-PTP-N2,Phogrin,Islet cell autoantigen-related protein,Receptor-type tyrosine-protein phosphatase N2
Background
Protein PTPRN2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

PTPRN2, also known as IA-2β or phogrin, is closely related to PTPRN and is predominantly expressed in neuroendocrine and neuronal tissues. Like PTPRN, PTPRN2 has a transmembrane region and an intracellular domain with a catalytically inactive phosphatase-like region. PTPRN2 plays a crucial role in insulin and neurotransmitter secretion by regulating secretory granule biogenesis, transport, and exocytosis. It is particularly involved in maintaining the structural integrity of granules and their exocytotic machinery. PTPRN2 is an autoantigen in type 1 diabetes, contributing to β-cell autoimmunity and destruction. It has also been implicated in neurological functions, including synaptic vesicle release and neurotransmitter regulation. Dysregulation of PTPRN2 has been associated with metabolic diseases and neuropsychiatric disorders, highlighting its significance in endocrine and neuronal cell function.

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