Mouse Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
546€ (96 tests)
Elisa kits for PTPRN
proveedor
Abbexareference
abx254379Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PTPRN concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PTPRN, also known as IA-2, is a receptor-like protein tyrosine phosphatase predominantly expressed in neuroendocrine tissues, particularly in pancreatic β-cells. Structurally, it features a single transmembrane domain and an intracellular region that lacks phosphatase activity due to critical residue substitutions. PTPRN functions as a key regulator of insulin secretion and is essential for the formation and stability of secretory granules in endocrine cells. It interacts with granule components to facilitate the docking and exocytosis of insulin and other hormones. PTPRN is also an autoantigen in type 1 diabetes mellitus (T1DM), where autoimmune responses against it lead to β-cell destruction. Its role in neuroendocrine cell function emphasizes its importance in glucose homeostasis and diabetes pathogenesis. Mutations or dysregulation of PTPRN have been implicated in metabolic disorders and neurodegenerative diseases.
Características del producto
category
ELISA Kits
immunogen target
Protein Tyrosine Phosphatase Receptor Type N (PTPRN)
reactivity
Mouse
test range
0.78 ng/ml - 50 ng/ml
sensitivity
0.47 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
IA2,IA-2,ICA512,R-PTP-N,IA-2/PTP,Islet cell autoantigen 3,PTP IA-2,Islet cell antigen 512,R-PTP-N,Receptor-type tyrosine-protein phosphatase-like N
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PTPRN
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
Human PTPRN(Protein Tyrosine Phosphatase Receptor Type N) ELISA Kit

proveedor
FineTestreference
EH3685reactivity
humanstatus
RUOPrecio a consultar
Ver másMouse PTPRN(Protein Tyrosine Phosphatase Receptor Type N) ELISA Kit

proveedor
FineTestreference
EM1322reactivity
mousestatus
RUOPrecio a consultar
Ver másRecombinant Human PTPRN

proveedor
FineTestreference
P1776Tested Applications
Western Blot, ELISAstatus
RUOPrecio a consultar
Ver más