Mouse Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Mouse Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

546€ (96 tests)

Elisa kits for PTPRN

proveedor

Abbexa

reference

abx254379

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PTPRN concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PTPRN, also known as IA-2, is a receptor-like protein tyrosine phosphatase predominantly expressed in neuroendocrine tissues, particularly in pancreatic β-cells. Structurally, it features a single transmembrane domain and an intracellular region that lacks phosphatase activity due to critical residue substitutions. PTPRN functions as a key regulator of insulin secretion and is essential for the formation and stability of secretory granules in endocrine cells. It interacts with granule components to facilitate the docking and exocytosis of insulin and other hormones. PTPRN is also an autoantigen in type 1 diabetes mellitus (T1DM), where autoimmune responses against it lead to β-cell destruction. Its role in neuroendocrine cell function emphasizes its importance in glucose homeostasis and diabetes pathogenesis. Mutations or dysregulation of PTPRN have been implicated in metabolic disorders and neurodegenerative diseases.

Características del producto

category

ELISA Kits


immunogen target

Protein Tyrosine Phosphatase Receptor Type N (PTPRN)


reactivity

Mouse


test range

0.78 ng/ml - 50 ng/ml


sensitivity

0.47 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

IA2,IA-2,ICA512,R-PTP-N,IA-2/PTP,Islet cell autoantigen 3,PTP IA-2,Islet cell antigen 512,R-PTP-N,Receptor-type tyrosine-protein phosphatase-like N


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PTPRN


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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