Human Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Protein
234€ (10 µg)
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Name
Human Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068777
Tested Applications
WB, SDS-PAGE
Description
Human Protein Tyrosine Phosphatase Receptor Type N (PTPRN) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type N (PTPRN) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Leu185-Leu367 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 20.7 kDa Observed MW (SDS-PAGE): 23 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16849 |
| Alias | IA2,IA-2,ICA512,R-PTP-N,IA-2/PTP,Islet cell autoantigen 3,PTP IA-2,Islet cell antigen 512,R-PTP-N,Receptor-type tyrosine-protein phosphatase-like N |
| Background | Protein PTPRN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 150 µg/ml |
Background
PTPRN, also known as IA-2, is a receptor-like protein tyrosine phosphatase predominantly expressed in neuroendocrine tissues, particularly in pancreatic β-cells. Structurally, it features a single transmembrane domain and an intracellular region that lacks phosphatase activity due to critical residue substitutions. PTPRN functions as a key regulator of insulin secretion and is essential for the formation and stability of secretory granules in endocrine cells. It interacts with granule components to facilitate the docking and exocytosis of insulin and other hormones. PTPRN is also an autoantigen in type 1 diabetes mellitus (T1DM), where autoimmune responses against it lead to β-cell destruction. Its role in neuroendocrine cell function emphasizes its importance in glucose homeostasis and diabetes pathogenesis. Mutations or dysregulation of PTPRN have been implicated in metabolic disorders and neurodegenerative diseases.
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