Mouse Programmed Cell Death 1 Ligand 1 (CD274) Protein (Active)
923€ (100 µg)
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935106861
info@markelab.com
name
Mouse Programmed Cell Death 1 Ligand 1 (CD274) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692065
tested applications
SDS-PAGE
Description
Mouse PD-L1 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse CD274 (NP_068693.1) extracellular domain (Met 1-Thr 238) was fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Programmed Cell Death 1 Ligand 1 (CD274) |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 26.3 kDa Sequence Fragment: Met1-Thr238 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 98% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_068693.1 |
| Alias | B7-H,B7H1,PDL,PD-L1,hPD-L1,PDCD1L1,PDCD1LG1,B7 homolog 1,PDCD1 ligand 1,Programmed death ligand 1,Programmed cell death 1 ligand 1 |
| Background | Protein CD274 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD274 molecule, also known as Programmed Death-Ligand 1 (PD-L1), is a critical component in the immune checkpoint pathway. Encoded by the CD274 gene located on chromosome 9p24.1, PD-L1 is primarily expressed on the surface of various cell types, including immune cells (such as T cells, B cells, dendritic cells, and macrophages) and non-immune cells (including epithelial and endothelial cells). Its expression can be upregulated in response to inflammatory signals, particularly interferon-gamma (IFN-γ). PD-L1 plays a vital role in maintaining immune homeostasis and preventing autoimmunity by regulating the activity of T cells. PD-L1 gained significant attention in cancer immunotherapy due to its role in tumor immune evasion. Many tumors exploit the PD-1/PD-L1 pathway to suppress anti-tumor immune responses, allowing cancer cells to escape immune surveillance
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