Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits ALKBH7
proveedor
Abbexareference
abx501569Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ALKBH7 is a mitochondrial dioxygenase that lacks canonical nucleic acid demethylase activity but instead regulates programmed necrosis and mitochondrial integrity. Unlike other ALKB family members, ALKBH7 is primarily involved in cellular energy metabolism and stress responses. It regulates mitochondrial homeostasis by influencing the permeability of the mitochondrial membrane and the release of reactive oxygen species (ROS). ALKBH7 is required for alkylation-induced necrosis, a form of programmed cell death triggered by genotoxic stress, where its loss impairs mitochondrial membrane potential and ROS generation. It has been shown to play a role in lipid metabolism and cellular response to alkylating agents. Dysregulation of ALKBH7 has been associated with resistance to alkylating chemotherapeutic agents, highlighting its importance in cancer cell death pathways. Emerging research suggests ALKBH7 as a potential target for enhancing cancer cell sensitivity to DNA damage-inducing therapies.
Características del producto
category
ELISA Kits
immunogen target
Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
ALKBH7,ABH7,SPATA11
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
ALKBH7
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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