Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7) ELISA Kit
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Description
Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9D6Z0 |
| Gene ID | 66400 |
| Alias | ALKBH7,ABH7,SPATA11 |
| Background | Elisa kits for ALKBH7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALKBH7 is a mitochondrial dioxygenase that lacks canonical nucleic acid demethylase activity but instead regulates programmed necrosis and mitochondrial integrity. Unlike other ALKB family members, ALKBH7 is primarily involved in cellular energy metabolism and stress responses. It regulates mitochondrial homeostasis by influencing the permeability of the mitochondrial membrane and the release of reactive oxygen species (ROS). ALKBH7 is required for alkylation-induced necrosis, a form of programmed cell death triggered by genotoxic stress, where its loss impairs mitochondrial membrane potential and ROS generation. It has been shown to play a role in lipid metabolism and cellular response to alkylating agents. Dysregulation of ALKBH7 has been associated with resistance to alkylating chemotherapeutic agents, highlighting its importance in cancer cell death pathways. Emerging research suggests ALKBH7 as a potential target for enhancing cancer cell sensitivity to DNA damage-inducing therapies.
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