AlkB Homolog 7 (ALKBH7) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Alkb, Alkylation Repair Homolog 7 (E. Coli) Antibody is a Rabbit Polyclonal antibody against Alkb, Alkylation Repair Homolog 7 (E. Coli).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AlkB Homolog 7 (ALKBH7) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BT30 |
| Gene ID | 84266 |
| OMIM | 613305 |
| Alias | ALKBH7,ABH7,SPATA11 |
| Background | Antibody anti-ALKBH7 |
| Status | RUO |
Descripción
ALKBH7 is a mitochondrial dioxygenase that lacks canonical nucleic acid demethylase activity but instead regulates programmed necrosis and mitochondrial integrity. Unlike other ALKB family members, ALKBH7 is primarily involved in cellular energy metabolism and stress responses. It regulates mitochondrial homeostasis by influencing the permeability of the mitochondrial membrane and the release of reactive oxygen species (ROS). ALKBH7 is required for alkylation-induced necrosis, a form of programmed cell death triggered by genotoxic stress, where its loss impairs mitochondrial membrane potential and ROS generation. It has been shown to play a role in lipid metabolism and cellular response to alkylating agents. Dysregulation of ALKBH7 has been associated with resistance to alkylating chemotherapeutic agents, highlighting its importance in cancer cell death pathways. Emerging research suggests ALKBH7 as a potential target for enhancing cancer cell sensitivity to DNA damage-inducing therapies.
Related Products
anti- ALKBH7 antibody
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110(in vitro), but this activity may be due to the absence of the true substrate(PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death(PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage(PubMed:23666923). Does not display DNA demethylase activity(PubMed:23666923). Involved in fatty acid metabolism(By similarity).
Ver Producto
AlkB Homolog 7 (ALKBH7) Antibody
ALKBH7 Antibody is a Rabbit Polyclonal antibody against ALKBH7.
Ver Producto
AlkB Homolog 7 (ALKBH7) Antibody
Alkb, Alkylation Repair Homolog 7 (E. Coli) Antibody is a Rabbit Polyclonal antibody against Alkb, Alkylation Repair Homolog 7 (E. Coli).
Ver Producto