Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH5 (ALKBH5) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH5 (ALKBH5) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501563
tested applications
ELISA
Description
Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH5 (ALKBH5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Probable alpha-ketoglutarate-dependent dioxygenase ABH5 (ALKBH5) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q3TSG4 |
| Gene ID | 268420 |
| Alias | ALKBH5,ABH5,OFOXD1 |
| Background | Elisa kits for ALKBH5 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALKBH5 is an α-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase that specifically catalyzes the demethylation of N6-methyladenosine (m6A), a major modification on mRNA. ALKBH5 is a key regulator of RNA metabolism, influencing mRNA stability, splicing, translation, and export. By removing m6A marks, ALKBH5 modulates gene expression, particularly during processes such as spermatogenesis, immune responses, and cancer progression. ALKBH5 is highly expressed in testicular tissues, where it regulates germ cell development and fertility. In cancer biology, ALKBH5 plays a critical role in tumor progression and metastasis by promoting the stability and translation of oncogenes and cancer-associated transcripts. Its upregulation has been observed in glioblastoma, breast cancer, and other tumors, where it contributes to chemoresistance and proliferation. Recent studies highlight ALKBH5 as a potential therapeutic target for disrupting cancer-associated RNA modifications and inhibiting tumor growth.
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Human ALKBH5 (RNA demethylase ALKBH5) ELISA Kit
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ALKBH5 antibody
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine(m6A) RNA, the most prevalent internal modification of messenger RNA(mRNA) in higher eukaryotes(PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA(in vitro)(PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export(PubMed:23177736). Required for spermatogenesis(By similarity).
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