ALKBH5 antibody

Este producto es parte de ALKBH - alkB homolog
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935106861
info@markelab.com
name
ALKBH5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00314
tested applications
ELISA, WB

Description

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine(m6A) RNA, the most prevalent internal modification of messenger RNA(mRNA) in higher eukaryotes(PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA(in vitro)(PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export(PubMed:23177736). Required for spermatogenesis(By similarity).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
alkB, alkylation repair homolog 5(E. coli) (ALKBH5)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
51 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q6P6C2
Gene ID
54890
Alias
ALKBH5,ABH5,OFOXD1
Background
Antibody anti-ALKBH5
Status
RUO
Note
Mol. Weight 51 kDa

Descripción

ALKBH5 is an α-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase that specifically catalyzes the demethylation of N6-methyladenosine (m6A), a major modification on mRNA. ALKBH5 is a key regulator of RNA metabolism, influencing mRNA stability, splicing, translation, and export. By removing m6A marks, ALKBH5 modulates gene expression, particularly during processes such as spermatogenesis, immune responses, and cancer progression. ALKBH5 is highly expressed in testicular tissues, where it regulates germ cell development and fertility. In cancer biology, ALKBH5 plays a critical role in tumor progression and metastasis by promoting the stability and translation of oncogenes and cancer-associated transcripts. Its upregulation has been observed in glioblastoma, breast cancer, and other tumors, where it contributes to chemoresistance and proliferation. Recent studies highlight ALKBH5 as a potential therapeutic target for disrupting cancer-associated RNA modifications and inhibiting tumor growth.

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