Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (ALKBH4) ELISA Kit

Este producto es parte de ALKBH - alkB homolog
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (ALKBH4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501560
tested applications
ELISA

Description

Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (ALKBH4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (ALKBH4)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9D8F1
Gene ID
72041
Alias
ALKBH4,ABH4
Background
Elisa kits for ALKBH4
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ALKBH4 is a nuclear enzyme that functions as a lysine demethylase, specifically targeting methylated lysine residues on non-histone proteins. ALKBH4 plays a critical role in cytoskeletal dynamics, particularly by demethylating actin, which regulates actin filament assembly and cellular motility. Its activity ensures proper cytokinesis, cell shape maintenance, and migration during mitosis and development. ALKBH4 also participates in DNA repair and gene regulation by interacting with other proteins involved in chromatin remodeling and transcription. Dysregulation of ALKBH4 is linked to defects in cell division, genomic instability, and impaired cellular motility, contributing to developmental abnormalities and cancer progression. In cancer biology, ALKBH4’s regulation of cytoskeletal dynamics has been shown to promote cancer cell invasion and metastasis. Its role in demethylating non-histone proteins distinguishes ALKBH4 from other ALKB family members, highlighting its importance in post-translational modification and cellular homeostasis.

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