ALKBH4 antibody

Este producto es parte de ALKBH - alkB homolog
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935106861
info@markelab.com
name
ALKBH4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00313
tested applications
ELISA, WB, IF

Description

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84'(K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
alkB, alkylation repair homolog 4(E. coli) (ALKBH4)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:200-1:2000; IHC: 1:10-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
34 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9NXW9
Gene ID
54784
Alias
ALKBH4,ABH4
Background
Antibody anti-ALKBH4
Status
RUO
Note
Mol. Weight 34 kDa

Descripción

ALKBH4 is a nuclear enzyme that functions as a lysine demethylase, specifically targeting methylated lysine residues on non-histone proteins. ALKBH4 plays a critical role in cytoskeletal dynamics, particularly by demethylating actin, which regulates actin filament assembly and cellular motility. Its activity ensures proper cytokinesis, cell shape maintenance, and migration during mitosis and development. ALKBH4 also participates in DNA repair and gene regulation by interacting with other proteins involved in chromatin remodeling and transcription. Dysregulation of ALKBH4 is linked to defects in cell division, genomic instability, and impaired cellular motility, contributing to developmental abnormalities and cancer progression. In cancer biology, ALKBH4’s regulation of cytoskeletal dynamics has been shown to promote cancer cell invasion and metastasis. Its role in demethylating non-histone proteins distinguishes ALKBH4 from other ALKB family members, highlighting its importance in post-translational modification and cellular homeostasis.

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