Mouse PHD finger protein 21A (PHF21A) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PHF21A
proveedor
Abbexareference
abx538474Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse PHD finger protein 21A (PHF21A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PHD finger protein 21A concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PHF21A is a PHD finger-containing protein involved in chromatin remodeling and transcriptional repression through its interactions with histone modifications. It is a component of the BHC complex, where it facilitates histone deacetylation and demethylation to suppress gene expression. PHF21A plays an essential role in neural development, where it regulates genes involved in neuronal differentiation, synaptic plasticity, and brain formation. It binds to unmethylated CpG islands and recruits chromatin modifiers to maintain gene silencing in a tissue-specific manner. Dysregulation or mutations in PHF21A are associated with neurodevelopmental disorders, including intellectual disability and Potocki-Shaffer syndrome, which manifest as craniofacial abnormalities and cognitive impairments. Knockout studies reveal disrupted neuronal differentiation, altered gene silencing, and developmental defects, highlighting its role in transcriptional repression, neurodevelopment, and chromatin regulation.
Características del producto
category
ELISA Kits
immunogen target
PHD finger protein 21A (PHF21A)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
BHC80, BM-006, IDDBCS, NEDMS,BHC80a
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PHF21A
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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