Mouse Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) Protein

Este producto es parte de PPARGC1A -  PPARG coactivator 1 alpha
Mouse Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein PPARGC1A

proveedor

Abbexa

reference

abx068505

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARGC1A) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

PPARGC1A, also known as PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), is a transcriptional coactivator that plays a central role in the regulation of cellular energy metabolism and mitochondrial biogenesis. PPARGC1A interacts with and coactivates various transcription factors, including peroxisome proliferator-activated receptor gamma (PPARG) and nuclear respiratory factors (NRFs), to regulate the expression of genes involved in energy metabolism, oxidative phosphorylation, and mitochondrial function. It promotes the transcription of genes involved in fatty acid oxidation, glucose metabolism, and thermogenesis, thereby enhancing cellular energy production and expenditure. PPARGC1A is a master regulator of mitochondrial biogenesis, the process by which new mitochondria are formed. It stimulates the expression of nuclear-encoded mitochondrial genes and activates signaling pathways involved in mitochondrial biogenesis, such as the PPAR signaling pathway and the AMP-activated protein kinase (AMPK) pathway. Increased PPARGC1A activity leads to the proliferation and remodeling of mitochondria, resulting in enhanced cellular energy capacity and metabolic efficiency.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 24.7 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys577-Asn766 Tag: N-terminal His tag


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

PPARGC1A


dry ice

No


availability

Shipped within 5-7 working days.


alias

LEM6,PGC1,PGC1A,PGC-1v,PPARGC1,PGC-1alpha,PGC-1(alpha)


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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