Mouse Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein PPARGC1A
proveedor
Abbexareference
abx068505Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARGC1A) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
PPARGC1A, also known as PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), is a transcriptional coactivator that plays a central role in the regulation of cellular energy metabolism and mitochondrial biogenesis. PPARGC1A interacts with and coactivates various transcription factors, including peroxisome proliferator-activated receptor gamma (PPARG) and nuclear respiratory factors (NRFs), to regulate the expression of genes involved in energy metabolism, oxidative phosphorylation, and mitochondrial function. It promotes the transcription of genes involved in fatty acid oxidation, glucose metabolism, and thermogenesis, thereby enhancing cellular energy production and expenditure. PPARGC1A is a master regulator of mitochondrial biogenesis, the process by which new mitochondria are formed. It stimulates the expression of nuclear-encoded mitochondrial genes and activates signaling pathways involved in mitochondrial biogenesis, such as the PPAR signaling pathway and the AMP-activated protein kinase (AMPK) pathway. Increased PPARGC1A activity leads to the proliferation and remodeling of mitochondria, resulting in enhanced cellular energy capacity and metabolic efficiency.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 24.7 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys577-Asn766 Tag: N-terminal His tag
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
PPARGC1A
dry ice
No
availability
Shipped within 5-7 working days.
alias
LEM6,PGC1,PGC1A,PGC-1v,PPARGC1,PGC-1alpha,PGC-1(alpha)
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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