Mouse Peroxisome Proliferator Activated Receptor Delta (PPARd) Protein
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Description
Recombinant PPARD is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Peroxisome Proliferator Activated Receptor Delta (PPARd) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 14.5 kDa Observed MW (SDS-PAGE): 18/19/20 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn29-Met147 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35396 |
| Alias | FAAR,NUC1,NUCI,NR1C2,NUCII,PPARB,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2 |
| Background | Protein PPARD |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Peroxisome proliferator activated receptor delta (PPARD) is another member of the peroxisome proliferator-activated receptor family that regulates the expression of genes involved in lipid metabolism, energy expenditure, and inflammation PPARD is widely expressed in tissues such as the liver, muscle, and adipose tissue, where it helps regulate fatty acid oxidation, glucose metabolism, and mitochondrial function It also plays a key role in regulating the oxidative stress response and modulating the balance between energy storage and energy expenditure PPARD activation has been linked to improvements in insulin sensitivity and lipid profile, making it a potential therapeutic target for metabolic diseases like type 2 diabetes and obesity Additionally, PPARD is involved in the regulation of inflammation and immune responses, and its dysregulation has been implicated in inflammatory diseases, atherosclerosis, and certain cancers Its role in promoting fat burning and mitochondrial function makes PPARD a promising target for the development of therapies aimed at enhancing metabolic health and combating obesity-related conditions
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Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
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Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
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