Mouse Paxillin (Pax) Protein

Este producto es parte de PAX - testicular Tissue Protein Li 134
Mouse Paxillin (Pax) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein PXN

proveedor

Abbexa

reference

abx167435

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Paxillin Protein is a recombinant Mouse protein expressed in E. coli.


Background

Paxillin (PXN) is a focal adhesion-associated adaptor protein that regulates cell adhesion, migration, and cytoskeletal organization by interacting with integrins, growth factor receptors, and signaling proteins at focal adhesions. It contains LIM domains and LD motifs, enabling it to recruit structural and signaling molecules such as focal adhesion kinase (FAK), vinculin, and Src kinases, coordinating actin cytoskeletal dynamics and mechanotransduction. Paxillin is critical for integrin-mediated signaling pathways, linking extracellular matrix (ECM) cues to intracellular processes like cell movement, proliferation, and survival. It plays a key role in embryonic development, tissue remodeling, and wound healing by modulating focal adhesion turnover and actomyosin contractility. Dysregulation of paxillin promotes cancer progression, metastasis, and drug resistance by enhancing cell migration, invasion, and survival signaling. Knockout studies reveal defects in focal adhesion formation, impaired cell motility, and developmental abnormalities, highlighting its essential role in cell adhesion, cytoskeletal regulation, and mechanotransduction.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Paxillin (Pax)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys347-Asp578 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

PXN


dry ice

No


availability

Shipped within 5-7 working days.


alias

PAX,testicular Tissue Protein Li 134


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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