Mouse PAX-interacting protein 1 (PAXIP1) ELISA Kit

Product specifications

ELISA Kits

PAX-interacting protein 1 (PAXIP1)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q6NZQ4

55982

CAGF28,CAGF29,PACIP1,PAXIP1L,PTIP,TNRC2,PAX transactivation activation domain-interacting protein

Elisa kits for PAXIP1

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

PAX Interacting Protein 1 (PAXIP1) is a multifunctional nuclear protein that plays a critical role in DNA damage response and repair, particularly through its involvement in homologous recombination repair by recruiting key repair factors to sites of DNA double-strand breaks. It interacts with transcription factor Pax proteins, modulating gene expression essential for embryonic development, cell cycle regulation, and differentiation processes. PAXIP1 is also a core component of histone methyltransferase complexes, where it helps mediate H3K4 methylation, a crucial epigenetic modification linked to transcriptional activation and chromatin structure regulation. Its activity influences diverse biological processes, including immune system development, as it is necessary for effective immunoglobulin class switch recombination in B cells. Aberrations in PAXIP1 expression or function are associated with impaired DNA repair and genomic instability, contributing to tumorigenesis and progression in various cancers. PAXIP1 also serves as a scaffolding protein, facilitating interactions between DNA repair enzymes and chromatin remodelers, ensuring proper response to genotoxic stress. Its regulation is controlled through phosphorylation, enabling dynamic association with chromatin and response proteins, underscoring its role as a pivotal regulator of genome integrity and transcriptional modulation.

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