Mouse Nitric Oxide Synthase, Inducible (NOS2) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse Nitric Oxide Synthase, Inducible (NOS2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068307
Tested Applications
WB, SDS-PAGE
Description
Mouse NOS2 is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Nitric Oxide Synthase, Inducible (NOS2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser868-Asp909 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 6.0 kDa Observed MW (SDS-PAGE): 10 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29477 |
| Alias | Inosl,Macrophage NOS,MAC-NOS,NOS type II,Peptidyl-cysteine S-nitrosylase NOS2,NOS2A |
| Background | Protein NOS2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
NOS2, also known as inducible nitric oxide synthase (iNOS), is an enzyme responsible for the production of nitric oxide (NO), a key signaling molecule involved in immune defense, inflammation, and vasodilation NOS2 is primarily expressed in macrophages, neutrophils, and other immune cells upon stimulation by pro-inflammatory cytokines like IFN-γ, TNF-α, or microbial components such as lipopolysaccharide (LPS) NOS2-derived NO plays a critical role in host defense by killing pathogens, including bacteria, fungi, and parasites, through oxidative stress and inhibition of microbial enzymes Dysregulated NOS2 activity contributes to chronic inflammation, sepsis, and tissue damage observed in diseases such as autoimmune disorders, asthma, and neurodegeneration In cancers, NO produced by NOS2 can have dual effects, promoting tumor growth by inducing angiogenesis and suppressing immune responses or inhibiting tumor progression through cytotoxicity Regulation of NOS2 is of therapeutic interest for modulating inflammation and oxidative stress in infectious diseases, cardiovascular dysfunction, and cancer
Productos relacionados
Nitric Oxide Synthase Inducible Phospho-Tyr151 (NOS2 pY151) Antibody
Rabbit polyclonal antibody against NOS2 protein. Immunogen region is N-terminal. Specificity is as follows for the react…
Ver producto
Nitric Oxide Synthase, Inducible (NOS2) Antibody
Rabbit polyclonal antibody against NOS2 protein. Immunogen region is N-terminal.…
Ver producto
Nitric Oxide Synthase, Inducible (NOS2) Antibody
Rabbit polyclonal antibody against NOS2 protein. Immunogen region is C-terminal.…
Ver producto