Mouse Membrane Cofactor Protein (CD46) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse Membrane Cofactor Protein (CD46) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Membrane Cofactor Protein (CD46) concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Membrane Cofactor Protein (CD46) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O88174 |
| Alias | MCP,TLX,AHUS2,MIC10,TRA2.10,Membrane cofactor protein,Trophoblast leukocyte common antigen |
| Background | Elisa kits for CD46 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CD46, also known as membrane cofactor protein (MCP), is a transmembrane glycoprotein that serves primarily as a regulatory component of the complement system, protecting host cells from complement-mediated damage. CD46 is widely expressed on almost all nucleated cells and plays a key role in immune regulation, ensuring that the complement system, which is responsible for clearing pathogens, does not attack the body’s own cells. CD46 does this by serving as a cofactor for the proteolytic cleavage of C3b and C4b, two crucial components of the complement pathway, which are inactivated by factor I. In addition to its role in the complement system, CD46 is involved in various immune functions, including modulation of T-cell responses, immune tolerance, and viral entry. Several viruses, such as the measles virus and human herpesvirus 6 (HHV-6), use CD46 as a receptor to gain entry into host cells, highlighting its involvement in viral pathogenesis.
Related Products
Bovine CD46(Membrane cofactor protein) ELISA Kit
Ver Producto
anti- CD46 antibody
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. Acts as a receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6(PubMed:10972291, PubMed:12663806, PubMed:12724329, PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes(PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).
Ver Producto