Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. Acts as a receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6(PubMed:10972291, PubMed:12663806, PubMed:12724329, PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes(PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).
Primary Antibodies
polyclonal
human,mouse
CD46 molecule, complement regulatory protein
Rabbit
IgG
Unconjugated
liquid
ELISA, WB, IP
50-56 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500-1:1000; IP: 1:200-1:1000
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
CD46
MCP, MIC10
This product is for research use only.
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