Mouse Lysophosphatidic Acid Receptor 3 (LPAR3) Protein

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1872€ (1 mg)

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935106861
info@markelab.com
name
Mouse Lysophosphatidic Acid Receptor 3 (LPAR3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654223
tested applications
WB, SDS-PAGE

Description

Mouse Lysophosphatidic Acid Receptor 3 (LPAR3) Protein is a Recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Lysophosphatidic Acid Receptor 3 (LPAR3)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Please enquire.

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
LPAR3,EDG7,Edg-7,GPCR,HOFNH30,LP-A3,LPA3,LPA receptor 3,endothelial differentiation gene 7,lysophosphatidic acid G-protein-coupled receptor 7
Background
Protein LPAR3
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

LPAR3 is a G protein-coupled receptor for lysophosphatidic acid (LPA), widely expressed in reproductive tissues, cardiovascular cells, and epithelial tissues. It signals through Gq, Gi, and G12/13 proteins, activating downstream pathways such as phospholipase C (PLC), MAPK, and Rho/ROCK. LPAR3 plays a crucial role in embryonic development, particularly in implantation, embryo spacing, and uterine function. Dysregulation of LPAR3 impairs fertility and embryonic viability, as evidenced in animal models. In cancer, LPAR3 promotes tumor progression, angiogenesis, and metastasis, particularly in breast, ovarian, and colorectal cancers. LPAR3 activation enhances cancer cell migration and survival, making it a key contributor to cancer aggressiveness. In the cardiovascular system, LPAR3 regulates vascular tone and endothelial cell function, contributing to blood vessel integrity. Dysregulated LPAR3 signaling has been implicated in chronic inflammation, atherosclerosis, and fibrotic diseases. Therapeutic strategies targeting LPAR3 aim to modulate its roles in reproduction, cancer, and inflammatory diseases.

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