Lysophosphatidic Acid Receptor 3 (LPAR3) Antibody

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637€ (100 µl)

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935106861
info@markelab.com
name
Lysophosphatidic Acid Receptor 3 (LPAR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx113557
tested applications
ELISA, WB

Description

LPAR3 Antibody is a Rabbit Polyclonal antibody against LPAR3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Lysophosphatidic Acid Receptor 3 (LPAR3)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9UBY5
Gene ID
23566
OMIM
605106
Alias
LPAR3,EDG7,Edg-7,GPCR,HOFNH30,LP-A3,LPA3,LPA receptor 3,endothelial differentiation gene 7,lysophosphatidic acid G-protein-coupled receptor 7
Background
Antibody anti-LPAR3
Status
RUO

Descripción

LPAR3 is a G protein-coupled receptor for lysophosphatidic acid (LPA), widely expressed in reproductive tissues, cardiovascular cells, and epithelial tissues. It signals through Gq, Gi, and G12/13 proteins, activating downstream pathways such as phospholipase C (PLC), MAPK, and Rho/ROCK. LPAR3 plays a crucial role in embryonic development, particularly in implantation, embryo spacing, and uterine function. Dysregulation of LPAR3 impairs fertility and embryonic viability, as evidenced in animal models. In cancer, LPAR3 promotes tumor progression, angiogenesis, and metastasis, particularly in breast, ovarian, and colorectal cancers. LPAR3 activation enhances cancer cell migration and survival, making it a key contributor to cancer aggressiveness. In the cardiovascular system, LPAR3 regulates vascular tone and endothelial cell function, contributing to blood vessel integrity. Dysregulated LPAR3 signaling has been implicated in chronic inflammation, atherosclerosis, and fibrotic diseases. Therapeutic strategies targeting LPAR3 aim to modulate its roles in reproduction, cancer, and inflammatory diseases.

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