Mouse Ltb4r (Leukotriene B4 receptor 1) ELISA Kit
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935106861
info@markelab.com
name
Mouse Ltb4r (Leukotriene B4 receptor 1) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EM0320
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.313-20ng/ml |
| Sensitivity | 0.188ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O88855 |
| Alias | LTB4R,BLT1,BLTR,CMKRL1,GPR16,LTB4R1,LTBR1,P2RY7,P2Y7,BLTR,GPR16 |
| Background | Elisa kits for Ltb4r |
| Status | RUO |
LTB4R, also known as BLT1, is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4), a potent lipid mediator derived from arachidonic acid. It is predominantly expressed on immune cells, such as neutrophils, monocytes, and T cells, where it regulates inflammatory responses and immune cell recruitment. Upon LTB4 binding, LTB4R activates downstream signaling pathways, including PI3K/Akt and MAPK, which promote chemotaxis, cytokine production, and reactive oxygen species (ROS) generation. LTB4R plays a critical role in acute and chronic inflammation, contributing to diseases such as asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). In cancer, LTB4R has been linked to tumor progression and metastasis by enhancing immune cell infiltration and angiogenesis within the tumor microenvironment. Dysregulated LTB4R signaling is also implicated in cardiovascular and metabolic disorders. Therapeutically, LTB4R antagonists are being developed to treat inflammatory and immune-mediated diseases by suppressing leukotriene B4-mediated responses, making it a key target for inflammation modulation.
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