Mouse Long-chain-fatty-acid--CoA ligase 5 (ACSL5) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Long-chain-fatty-acid--CoA ligase 5 (ACSL5) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500885
tested applications
ELISA
Description
Mouse Long-chain-fatty-acid--CoA ligase 5 (ACSL5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Long-chain-fatty-acid--CoA ligase 5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Long-chain-fatty-acid--CoA ligase 5 (ACSL5) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8JZR0 |
| Gene ID | 433256 |
| Alias | ACS2,ACS5,DIAR13,FACL5 |
| Background | Elisa kits for ACSL5 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACSL5 is a mitochondrial and cytosolic enzyme that activates long-chain fatty acids, particularly those with a preference for saturated and monounsaturated fatty acids, by converting them into acyl-CoA derivatives. ACSL5 is expressed in tissues like the small intestine, liver, and skeletal muscle, where it supports energy production, lipid absorption, and storage. This enzyme plays a crucial role in directing fatty acids toward oxidation or triglyceride synthesis, depending on metabolic demands, and is essential for maintaining energy homeostasis during fasting or high-fat diets. Dysregulation of ACSL5 has been implicated in metabolic disorders, such as obesity, diabetes, and non-alcoholic fatty liver disease, as altered fatty acid activation can lead to lipid accumulation and insulin resistance. ACSL5’s dual localization and specificity underscore its adaptability in regulating systemic and cellular lipid metabolism under diverse metabolic conditions.
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Acyl-CoA synthetases(ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage(By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids(By similarity). It was suggested that it may also stimulate fatty acid oxidation(By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
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