Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ACSL5 Antibody is a Rabbit Polyclonal antibody against ACSL5. Acyl-CoA synthetase 5, a member of the ACSL gene family that catalyzes the activation of long-chain fatty acids for lipid biosynthesis, is the only ACSL isoform that is both, located on mitochondria and functionally involved in enterocyte apoptosis.ACSL5 could play a role in promoting fatty acid-induced lipoapoptosis in hepatocytes as important mechanism in fatty liver-related disorders(PMID:20470896). ACSL5 is most abundant in liver, brown adipose tissue, and intestine and is located on both the mitochondrial membrane and endoplasmic reticulum(PMID:20798351). It has 3 isoforms produced by alternative splicing. This antibody is specific to ACSL5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULC5 |
| Gene ID | 51703 |
| NCBI Accession | NP_057318.2 |
| Alias | ACS2,ACS5,DIAR13,FACL5 |
| Background | Antibody anti-ACSL5 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
ACSL5 is a mitochondrial and cytosolic enzyme that activates long-chain fatty acids, particularly those with a preference for saturated and monounsaturated fatty acids, by converting them into acyl-CoA derivatives. ACSL5 is expressed in tissues like the small intestine, liver, and skeletal muscle, where it supports energy production, lipid absorption, and storage. This enzyme plays a crucial role in directing fatty acids toward oxidation or triglyceride synthesis, depending on metabolic demands, and is essential for maintaining energy homeostasis during fasting or high-fat diets. Dysregulation of ACSL5 has been implicated in metabolic disorders, such as obesity, diabetes, and non-alcoholic fatty liver disease, as altered fatty acid activation can lead to lipid accumulation and insulin resistance. ACSL5’s dual localization and specificity underscore its adaptability in regulating systemic and cellular lipid metabolism under diverse metabolic conditions.
Related Products
anti- ACSL5 antibody
Acyl-CoA synthetases(ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage(By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids(By similarity). It was suggested that it may also stimulate fatty acid oxidation(By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Ver Producto
Recombinant Human ACSL5
Ver Producto
Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) Antibody
ACSL5 Antibody is a Rabbit Polyclonal antibody against ACSL5. Acyl-CoA synthetase 5, a member of the ACSL gene family that catalyzes the activation of long-chain fatty acids for lipid biosynthesis, is the only ACSL isoform that is both, located on mitochondria and functionally involved in enterocyte apoptosis.ACSL5 could play a role in promoting fatty acid-induced lipoapoptosis in hepatocytes as important mechanism in fatty liver-related disorders(PMID:20470896). ACSL5 is most abundant in liver, brown adipose tissue, and intestine and is located on both the mitochondrial membrane and endoplasmic reticulum(PMID:20798351). It has 3 isoforms produced by alternative splicing. This antibody is specific to ACSL5.
Ver Producto