Mouse Linker For Activation Of T-Cells Family, Member 2 (LAT2) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein LAT2
proveedor
Abbexareference
abx168382Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Linker For Activation Of T-Cells Family, Member 2 Protein is a recombinant Mouse protein expressed in E. coli.
Background
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Linker For Activation Of T-Cells Family, Member 2 (LAT2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 22.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys29-Val193 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
LAT2
dry ice
No
availability
Shipped within 5-7 working days.
alias
LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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