Human Linker For Activation Of T-Cells Family, Member 2 (LAT2) Protein
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Description
Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Linker For Activation Of T-Cells Family, Member 2 (LAT2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg30-Met209 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9GZY6 |
| Alias | LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046 |
| Background | Protein LAT2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
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