Mouse Leukosialin (SPN) Protein
923€ (50 µg)
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935106861
info@markelab.com
name
Mouse Leukosialin (SPN) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691120
tested applications
SDS-PAGE
Description
Mouse SPN Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse SPN (P15702) (Met 1-Gly 248) was fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SPN |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 49.6 kDa Sequence Fragment: Met1-Gly248 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 80% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15702 |
| Alias | LSN,CD43,GALGP,GPL115,LEU-22,Leukosialin, Galactoglycoprotein,Leukocyte sialoglycoprotein,Sialophorin |
| Background | Protein SPN |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Sialophorin (SPN), also known as CD43, is a glycoprotein primarily expressed on the surface of immune cells, such as T lymphocytes, monocytes, neutrophils, and some B cells. SPN is involved in various aspects of immune cell function, including cell adhesion, migration, and activation. The molecule plays a critical role in modulating the interaction between immune cells and their microenvironment, particularly by regulating the adhesion properties of leukocytes, which are essential for their migration and trafficking through different tissues. Sialophorin is a highly sialylated protein, meaning it has many sialic acid residues attached to its extracellular portion, which contribute to its negative charge. This negative charge facilitates electrostatic repulsion between cells, which can prevent adhesion in certain contexts but also enables its participation in finely tuned immune responses. SPN is an important player in the immune system's ability to differentiate between self and non-self, contributing to immune surveillance and cellular interactions during inflammatory responses.
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