SPN antibody
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935106861
info@markelab.com
name
SPN antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01481
tested applications
ELISA, IHC, WB
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | sialophorin (SPN) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 6G11 |
| Observed MW | 115 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P16150 |
| Gene ID | 6693 |
| Alias | LSN,CD43,GALGP,GPL115,LEU-22,Leukosialin, Galactoglycoprotein,Leukocyte sialoglycoprotein,Sialophorin |
| Background | Antibody anti-SPN |
| Status | RUO |
| Note | Mol. Weight 115 kDa |
Sialophorin (SPN), also known as CD43, is a glycoprotein primarily expressed on the surface of immune cells, such as T lymphocytes, monocytes, neutrophils, and some B cells. SPN is involved in various aspects of immune cell function, including cell adhesion, migration, and activation. The molecule plays a critical role in modulating the interaction between immune cells and their microenvironment, particularly by regulating the adhesion properties of leukocytes, which are essential for their migration and trafficking through different tissues. Sialophorin is a highly sialylated protein, meaning it has many sialic acid residues attached to its extracellular portion, which contribute to its negative charge. This negative charge facilitates electrostatic repulsion between cells, which can prevent adhesion in certain contexts but also enables its participation in finely tuned immune responses. SPN is an important player in the immune system's ability to differentiate between self and non-self, contributing to immune surveillance and cellular interactions during inflammatory responses.
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