Mouse Leucine-rich repeat-containing protein 51 (LRRC51) ELISA Kit

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse Leucine-rich repeat-containing protein 51 (LRRC51) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx531429
tested applications
ELISA

Description

Mouse Leucine-rich repeat-containing protein 51 (LRRC51) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Leucine-rich repeat-containing protein 51 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Leucine-rich repeat-containing protein 51 (LRRC51)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9DAK8
Gene ID
69358
Alias
LRRC51,LRTOMT,Protein LRTOMT1
Background
Elisa kits for LRRC51
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

LRRC51 is a key component of the CATSPER complex, a calcium channel specifically located in the flagellum of sperm cells that regulates sperm motility and hyperactivation, essential for fertilization. It contains leucine-rich repeats (LRRs) that mediate protein-protein interactions, enabling it to assemble and stabilize the CATSPER channel alongside other subunits like CATSPER1-4 and LRRC52. LRRC51 plays a critical role in mediating calcium influx into sperm in response to physiological cues, allowing flagellar beating and hyperactivation during capacitation. Mutations or dysfunction of LRRC51 result in impaired sperm motility and male infertility, as the CATSPER complex is non-functional without its proper assembly. LRRC51 is exclusively expressed in the testes, specifically in mature sperm cells, underscoring its role in reproductive biology. Knockout models exhibit severely compromised sperm motility, defects in capacitation, and infertility, emphasizing its essential function in sperm function and male fertility.
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