Mouse Leucine-rich repeat-containing protein 51 (LRRC51) ELISA Kit

Name: Mouse Leucine-rich repeat-containing protein 51 (LRRC51) ELISA Kit
Brand: Abbexa
SKU: abx531429
Price: 687.5 EUR
Availability: OnlineOnly

Este producto es parte de LRRC - Leucine-rich repeat-containing protein

Pida mas información

935106861

info@markelab.com

Precio

687.5€ (96 tests)

Elisa Kits LRRC51

proveedor

Abbexa

reference

abx531429

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Leucine-rich repeat-containing protein 51 (LRRC51) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Leucine-rich repeat-containing protein 51 concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

LRRC51 is a key component of the CATSPER complex, a calcium channel specifically located in the flagellum of sperm cells that regulates sperm motility and hyperactivation, essential for fertilization. It contains leucine-rich repeats (LRRs) that mediate protein-protein interactions, enabling it to assemble and stabilize the CATSPER channel alongside other subunits like CATSPER1-4 and LRRC52. LRRC51 plays a critical role in mediating calcium influx into sperm in response to physiological cues, allowing flagellar beating and hyperactivation during capacitation. Mutations or dysfunction of LRRC51 result in impaired sperm motility and male infertility, as the CATSPER complex is non-functional without its proper assembly. LRRC51 is exclusively expressed in the testes, specifically in mature sperm cells, underscoring its role in reproductive biology. Knockout models exhibit severely compromised sperm motility, defects in capacitation, and infertility, emphasizing its essential function in sperm function and male fertility.

Características del producto

immunogen target

Leucine-rich repeat-containing protein 51 (LRRC51)

reactivity

Mouse

test range

0.156 ng/ml - 10 ng/ml

assay data

Quantitative

detection method

Colorimetric

sample type

Tissue homogenates,Cell lysates,Other biological fluids

size 1

96 tests

alias

LRRC51,LRTOMT,Protein LRTOMT1

storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit

or code

LRRC51

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q9DAK8

gene id

https://www.ncbi.nlm.nih.gov/gene/69358

note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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