Mouse Leucine-rich repeat-containing protein 17 (LRRC17) ELISA Kit

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse Leucine-rich repeat-containing protein 17 (LRRC17) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx531350
tested applications
ELISA

Description

Mouse Leucine-rich repeat-containing protein 17 (LRRC17) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Leucine-rich repeat-containing protein 17 concentrations in serum, plasma and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Leucine-rich repeat-containing protein 17 (LRRC17)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9CXD9
Gene ID
74511
Alias
LRRC18,UNQ9338/PRO34010
Background
Elisa kits for LRRC17
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

LRRC17 is a secreted protein that plays a role in modulating bone remodeling and immune responses by acting as a negative regulator of receptor activator of nuclear factor kappa-B ligand (RANKL) signaling it inhibits osteoclast differentiation and activity thereby contributing to bone homeostasis its expression in osteoblasts and other stromal cells is upregulated during bone remodeling processes making it an important factor in maintaining bone density and preventing osteoporotic conditions LRRC17 has also been implicated in cancer metastasis particularly to the bone as its dysregulation can create an osteolytic environment supportive of tumor progression it is expressed in various tissues where it modulates immune responses through interactions with cytokines and receptors although its precise mechanism in immune regulation is not fully understood studies have linked LRRC17 to the modulation of chronic inflammatory states and tumor microenvironments research continues to focus on its dual role in bone biology and cancer to identify therapeutic strategies for bone-related diseases and metastatic cancers
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