Mouse Junctional Adhesion Molecule 2 (JAM2) Protein (Active)

Este producto es parte de JAM - junctional adhesion molecule
Product Graph
1079€ (100 µg)

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935106861
info@markelab.com
name
Mouse Junctional Adhesion Molecule 2 (JAM2) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692079
tested applications
SDS-PAGE

Description

Mouse JAM2 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse JAM2 (NP_076333.3) (Met 1-Asn 236) was expressed, with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
JAM2
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 24.7 kDa
Sequence Fragment: Met1-Asn236
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 97% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_076333.3
Alias
JAMB,CD322,IBGC8,JAM-B,VEJAM,PRO245,VE-JAM,C21orf43,Vascular endothelial junction-associated molecule,Junctional adhesion molecule B
Background
Protein JAM2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

JAM2 is a member of the Junctional Adhesion Molecule (JAM) family, part of the immunoglobulin superfamily, and is primarily expressed in endothelial cells, lymphatic vessels, and certain immune cells. Structurally, JAM2 consists of two extracellular Ig-like domains, a single transmembrane domain, and a short cytoplasmic tail that interacts with intracellular signaling molecules and the actin cytoskeleton. JAM2 is involved in cell-cell adhesion, particularly in maintaining endothelial barrier integrity and regulating the movement of immune cells through endothelial junctions. It plays a role in leukocyte transmigration during inflammation and immune surveillance by interacting with integrins, including α4β1 integrin on leukocytes. JAM2 also mediates vascular permeability and contributes to the organization of tight junctions between endothelial and epithelial cells. JAM2 is implicated in pathological processes such as inflammatory diseases, autoimmunity, and cancer metastasis, where it regulates the extravasation of leukocytes and cancer cells. Dysregulation of JAM2 has been linked to abnormal vascular permeability and inflammatory responses, making it a potential therapeutic target in conditions like vascular inflammation and tumor progression.

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