Junctional Adhesion Molecule 2 (JAM2) Antibody
292.5€ (80 µl)
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935106861
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name
Junctional Adhesion Molecule 2 (JAM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx027880
tested applications
ELISA, WB, IHC
Description
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. [provided by RefSeq].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Junctional Adhesion Molecule 2 (JAM2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P57087 |
| Alias | JAMB,CD322,IBGC8,JAM-B,VEJAM,PRO245,VE-JAM,C21orf43,Vascular endothelial junction-associated molecule,Junctional adhesion molecule B |
| Background | Antibody anti-JAM2 |
| Status | RUO |
Descripción
JAM2 is a member of the Junctional Adhesion Molecule (JAM) family, part of the immunoglobulin superfamily, and is primarily expressed in endothelial cells, lymphatic vessels, and certain immune cells. Structurally, JAM2 consists of two extracellular Ig-like domains, a single transmembrane domain, and a short cytoplasmic tail that interacts with intracellular signaling molecules and the actin cytoskeleton. JAM2 is involved in cell-cell adhesion, particularly in maintaining endothelial barrier integrity and regulating the movement of immune cells through endothelial junctions. It plays a role in leukocyte transmigration during inflammation and immune surveillance by interacting with integrins, including α4β1 integrin on leukocytes. JAM2 also mediates vascular permeability and contributes to the organization of tight junctions between endothelial and epithelial cells. JAM2 is implicated in pathological processes such as inflammatory diseases, autoimmunity, and cancer metastasis, where it regulates the extravasation of leukocytes and cancer cells. Dysregulation of JAM2 has been linked to abnormal vascular permeability and inflammatory responses, making it a potential therapeutic target in conditions like vascular inflammation and tumor progression.
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