Mouse Interleukin 8 Receptor Beta / IL8RB (CXCR2) Peptide
312€ (50 µg)
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935106861
info@markelab.com
name
Mouse Interleukin 8 Receptor Beta / IL8RB (CXCR2) Peptide
category
Proteins and Peptides
provider
Abbexa
reference
abx654068
tested applications
BL
Description
Mouse Interleukin 8 Receptor Beta (IL8Rb) Peptide is a synthetic peptide.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 8 Receptor Beta / IL8RB (CXCR2) |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu3-Asp13 |
| Expression | Synthetic |
| Purity | > 95% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | BL |
| Buffer | Prior to lyophilization: 10 mM PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CXCR2,C-X-C motif chemokine receptor 2,CD182,IL8R2,IL8RA,IL8RB,CMKAR2,WHIMS2,CDw128b,KC receptor,CXC-R2,high affinity interleukin-8 receptor B,CD128,Gpcr16 |
| Background | Protein CXCR2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CXCR2 is a G protein-coupled receptor that binds IL-8 and other CXC chemokines like Groα, Groβ, and NAP-2. It is mainly expressed on neutrophils, endothelial cells, and monocytes, mediating chemotaxis, neutrophil activation, and cytokine release during inflammation. CXCR2 signaling activates pathways such as PI3K, MAPK, and NF-κB, while its rapid desensitization and internalization regulate signal duration. CXCR2 is critical for immune surveillance and inflammation but also contributes to diseases like COPD, asthma, and rheumatoid arthritis due to excessive neutrophil infiltration. In cancer, CXCR2 promotes tumor progression, angiogenesis, and metastasis by recruiting myeloid-derived suppressor cells (MDSCs) and endothelial cells to the tumor microenvironment, enhancing immunosuppression and vascularization. CXCR2 inhibition reduces tumor growth and inflammation, highlighting its therapeutic potential. It also regulates leukocyte trafficking and tissue repair but contributes to pathologies like cystic fibrosis and inflammatory bowel disease (IBD) when dysregulated. Overall, CXCR2 is key for immune cell recruitment and inflammation, balancing host defense with disease progression.
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