Mouse Interleukin 18 Receptor 1 (IL18R1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits IL18R1
proveedor
Abbexareference
abx389635Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Interleukin 18 Receptor 1 (IL18R1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse IL18R1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
IL18R1 is a key receptor in the interleukin-18 (IL-18) signaling pathway, mediating pro-inflammatory immune responses and host defense mechanisms. It forms a heterodimeric complex with IL18RAP (Interleukin 18 Receptor Accessory Protein) upon IL-18 ligand binding, leading to the recruitment of the MyD88 adaptor protein and activation of downstream NF-κB, MAPK, and JNK pathways. IL18R1 is highly expressed on immune cells, including T cells, natural killer (NK) cells, and macrophages, where it plays critical roles in cytokine production, immune cell activation, and Th1 immune responses. It contributes to the regulation of inflammation, pathogen defense, and tissue repair in response to infections, stress, and inflammatory stimuli. Dysregulation of IL18R1 is linked to autoimmune diseases, chronic inflammation, and cancers, where excessive IL-18 signaling promotes tissue damage and tumor progression. Knockout studies reveal impaired cytokine production, reduced NK cell activation, and weakened pathogen clearance, underscoring its critical role in innate and adaptive immunity, inflammatory signaling, and immune surveillance.
Características del producto
category
ELISA Kits
immunogen target
Interleukin 18 Receptor 1 (IL18R1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.094 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
L18R1, CD218a, CDw218a,IL-18Ralpha,IL-18 R alpha,IL-1 R5,IL-18RA,IL18RA,IL1RRP
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
IL18R1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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