Mouse Interleukin 18 Receptor 1 (IL18R1) ELISA Kit

Este producto es parte de IL18R1 - Interleukin 18 Receptor 1
Mouse Interleukin 18 Receptor 1 (IL18R1) ELISA Kit
715€ (96 tests)

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Name
Mouse Interleukin 18 Receptor 1 (IL18R1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx389635
Tested Applications
ELISA

Description

Mouse Interleukin 18 Receptor 1 (IL18R1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse IL18R1 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Interleukin 18 Receptor 1 (IL18R1)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.094 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q61098
Gene ID
16182
Alias
L18R1, CD218a, CDw218a,IL-18Ralpha,IL-18 R alpha,IL-1 R5,IL-18RA,IL18RA,IL1RRP
Background
Elisa Kits for: IL18R1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

IL18R1 is a key receptor in the interleukin-18 (IL-18) signaling pathway, mediating pro-inflammatory immune responses and host defense mechanisms. It forms a heterodimeric complex with IL18RAP (Interleukin 18 Receptor Accessory Protein) upon IL-18 ligand binding, leading to the recruitment of the MyD88 adaptor protein and activation of downstream NF-κB, MAPK, and JNK pathways. IL18R1 is highly expressed on immune cells, including T cells, natural killer (NK) cells, and macrophages, where it plays critical roles in cytokine production, immune cell activation, and Th1 immune responses. It contributes to the regulation of inflammation, pathogen defense, and tissue repair in response to infections, stress, and inflammatory stimuli. Dysregulation of IL18R1 is linked to autoimmune diseases, chronic inflammation, and cancers, where excessive IL-18 signaling promotes tissue damage and tumor progression. Knockout studies reveal impaired cytokine production, reduced NK cell activation, and weakened pathogen clearance, underscoring its critical role in innate and adaptive immunity, inflammatory signaling, and immune surveillance.

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