Interleukin 18 Receptor 1 (IL18R1) Antibody
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Description
Rabbit Polyclonal against the IL18R1 protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 18 Receptor 1 (IL18R1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | L18R1, CD218a, CDw218a,IL-18Ralpha,IL-18 R alpha,IL-1 R5,IL-18RA,IL18RA,IL1RRP |
| Background | Antibody anti-IL18R1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
IL18R1 is a key receptor in the interleukin-18 (IL-18) signaling pathway, mediating pro-inflammatory immune responses and host defense mechanisms. It forms a heterodimeric complex with IL18RAP (Interleukin 18 Receptor Accessory Protein) upon IL-18 ligand binding, leading to the recruitment of the MyD88 adaptor protein and activation of downstream NF-κB, MAPK, and JNK pathways. IL18R1 is highly expressed on immune cells, including T cells, natural killer (NK) cells, and macrophages, where it plays critical roles in cytokine production, immune cell activation, and Th1 immune responses. It contributes to the regulation of inflammation, pathogen defense, and tissue repair in response to infections, stress, and inflammatory stimuli. Dysregulation of IL18R1 is linked to autoimmune diseases, chronic inflammation, and cancers, where excessive IL-18 signaling promotes tissue damage and tumor progression. Knockout studies reveal impaired cytokine production, reduced NK cell activation, and weakened pathogen clearance, underscoring its critical role in innate and adaptive immunity, inflammatory signaling, and immune surveillance.
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