Mouse Interleukin 10 (IL10) Protein

Este producto es parte de IL10 - Interleukin 10
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234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Interleukin 10 (IL10) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067423
tested applications
WB, SDS-PAGE

Description

Recombinant Interleukin 10 (IL10) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Interleukin 10 (IL10)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 23.5 kDa  Observed MW: 23 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ser19-Ser178

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P18893
Alias
CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor
Background
Protein IL10
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections

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