Mouse Intercellular Adhesion Molecule 2 / CD102 (ICAM2) Protein (Active)
1235€ (100 µg)
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Name
Mouse Intercellular Adhesion Molecule 2 / CD102 (ICAM2) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693658
Tested Applications
SDS-PAGE
Description
Mouse ICAM-2 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse ICAM2 (NP_034624.1) (Met 1-Gln 222)was expressed with six amino acids (LEVLFQ) at the C-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | ICAM-2 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Gln222 |
| Origin | Mouse |
| Observed MW | 23.6 kDa |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_034624.1 |
| Alias | Intercellular adhesion molecule 2,CD102,ICAM-2 |
| Background | Protein ICAM2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method. |
Background
Intercellular adhesion molecule 2 (ICAM2) is a member of the immunoglobulin superfamily and plays an essential role in immune cell trafficking, endothelial integrity, and cell signaling. ICAM-2 is encoded by the ICAM2 gene and, along with other intercellular adhesion molecules, serves as a ligand for leukocyte integrins such as LFA-1 (lymphocyte function-associated antigen-1), facilitating the adhesion and transmigration of leukocytes across endothelial cells. It is broadly expressed on endothelial cells, leukocytes, and various other cell types. ICAM-2 is involved in vascular and immune system homeostasis, with roles extending to inflammation, cancer, and neurological functions. Unlike ICAM-1, which is inducible by inflammatory cytokines, ICAM-2 is constitutively expressed but has been found to increase in certain pathophysiological conditions, especially involving endothelial activation. The stable presence of ICAM-2 on endothelial cells makes it significant for lymphocyte recirculation and endothelial-leukocyte interactions, aiding immune surveillance and response to pathogens.
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