Intercellular Adhesion Molecule 2 / CD102 (ICAM2) Antibody

Este producto es parte de ICAM2 - intercellular adhesion molecule 2
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195€ (20 µl)

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935106861
info@markelab.com
name
Intercellular Adhesion Molecule 2 / CD102 (ICAM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001655
tested applications
ELISA, WB

Description

ICAM2 Antibody is a Rabbit Polyclonal antibody against ICAM2. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Intercellular Adhesion Molecule 2 / CD102 (ICAM2)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
20 µl
Size 2
100 µl
Size 3
2 × 100 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P13598
Gene ID
3384
NCBI Accession
NP_000864.2
Alias
Intercellular adhesion molecule 2,CD102,ICAM-2
Background
Antibody anti-ICAM2
Status
RUO
Note
Concentration: > 0.2 mg/ml - 

Descripción

Intercellular adhesion molecule 2 (ICAM2) is a member of the immunoglobulin superfamily and plays an essential role in immune cell trafficking, endothelial integrity, and cell signaling. ICAM-2 is encoded by the ICAM2 gene and, along with other intercellular adhesion molecules, serves as a ligand for leukocyte integrins such as LFA-1 (lymphocyte function-associated antigen-1), facilitating the adhesion and transmigration of leukocytes across endothelial cells. It is broadly expressed on endothelial cells, leukocytes, and various other cell types. ICAM-2 is involved in vascular and immune system homeostasis, with roles extending to inflammation, cancer, and neurological functions. Unlike ICAM-1, which is inducible by inflammatory cytokines, ICAM-2 is constitutively expressed but has been found to increase in certain pathophysiological conditions, especially involving endothelial activation. The stable presence of ICAM-2 on endothelial cells makes it significant for lymphocyte recirculation and endothelial-leukocyte interactions, aiding immune surveillance and response to pathogens.

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