Mouse Integrin Alpha-E / CD103 (ITGAE) Protein

Este producto es parte de ITGAE - integrin subunit alpha E
Mouse Integrin Alpha-E / CD103 (ITGAE) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ITGAE

proveedor

Abbexa

reference

abx067279

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse Integrin Alpha E (ITGaE) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

Integrin subunit alpha E, known as ITGAE, is a critical component of the immune system, particularly in regulating immune cell retention in epithelial tissues. ITGAE, often referred to as CD103 in immunological contexts, partners with the integrin beta 7 subunit to form the heterodimeric receptor αEβ7. This integrin is specifically expressed on subsets of immune cells, including mucosal T lymphocytes, dendritic cells, and natural killer (NK) cells, where it binds to E-cadherin, an adhesion molecule on epithelial cells. By binding E-cadherin, αEβ7 plays a critical role in localizing lymphocytes to epithelial tissues, particularly within the gut, skin, and lungs, where immune surveillance is essential. This adhesion mechanism enables αEβ7-expressing cells to provide targeted immune responses and maintain tissue integrity.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Integrin Alpha-E / CD103 (ITGAE)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 31.6 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val671-Gln917 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ITGAE


dry ice

No


availability

Shipped within 5-7 working days.


alias

CD103,HUMINAE,Integrin alpha-E,HML-1 antigen,Integrin alpha-IEL,Mucosal lymphocyte 1 antigen


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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status

RUO

clonality

polyclonal

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reference

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reactivity

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status

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clonality

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