Mouse Integrin Alpha-E / CD103 (ITGAE) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ITGAE
proveedor
Abbexareference
abx067279Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Integrin Alpha E (ITGaE) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
Integrin subunit alpha E, known as ITGAE, is a critical component of the immune system, particularly in regulating immune cell retention in epithelial tissues. ITGAE, often referred to as CD103 in immunological contexts, partners with the integrin beta 7 subunit to form the heterodimeric receptor αEβ7. This integrin is specifically expressed on subsets of immune cells, including mucosal T lymphocytes, dendritic cells, and natural killer (NK) cells, where it binds to E-cadherin, an adhesion molecule on epithelial cells. By binding E-cadherin, αEβ7 plays a critical role in localizing lymphocytes to epithelial tissues, particularly within the gut, skin, and lungs, where immune surveillance is essential. This adhesion mechanism enables αEβ7-expressing cells to provide targeted immune responses and maintain tissue integrity.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Integrin Alpha-E / CD103 (ITGAE)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 31.6 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val671-Gln917 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ITGAE
dry ice
No
availability
Shipped within 5-7 working days.
alias
CD103,HUMINAE,Integrin alpha-E,HML-1 antigen,Integrin alpha-IEL,Mucosal lymphocyte 1 antigen
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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proveedor
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
proveedor
Abbexareference
abx067279Tested Applications
WB, SDS-PAGEstatus
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