Mouse Integrin Alpha 5 (ITGA5) ELISA Kit
715€ (96 tests)
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name
Mouse Integrin Alpha 5 (ITGA5) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx521009
tested applications
ELISA
Description
Mouse Integrin Alpha 5 (ITGA5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Integrin alpha-5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Integrin Alpha 5 (ITGA5) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P11688 |
| Alias | FNRA,CD49e,VLA-5,VLA5A,Integrin alpha-5,Integrin alpha-5,Fibronectin receptor subunit alpha,Integrin alpha-F |
| Background | Elisa kits for ITGA5 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Integrin subunit alpha 5 (ITGA5) is a critical component of the integrin family of transmembrane receptors, responsible for mediating interactions between cells and the extracellular matrix (ECM). ITGA5 pairs with integrin subunit beta 1 (ITGB1) to form the α5β1 integrin, also known as the fibronectin receptor. This integrin complex plays an essential role in cell adhesion, migration, proliferation, and survival by binding to fibronectin, an ECM glycoprotein. ITGA5-mediated interactions are important for various physiological processes, including embryonic development, wound healing, angiogenesis, and the regulation of cell differentiation. Dysregulation of ITGA5 has been implicated in several pathologies, such as fibrosis, cancer, and inflammatory diseases.
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ITGA5 antibody
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site(site 2) which is distinct from the classical ligand-binding site(site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1(FBN1) and mediates R-G-D-dependent cell adhesion to FBN1(PubMed:12807887, PubMed:17158881).
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