Mouse Insulin Receptor Substrate 1 (IRS1) Protein

Este producto es parte de IRS -Insulin receptor substrate
Mouse Insulin Receptor Substrate 1 (IRS1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein IRS1

proveedor

Abbexa

reference

abx067268

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse Insulin Receptor Substrate 1 (IRS1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

IRS1 is a key adaptor protein that mediates insulin and insulin-like growth factor (IGF) signaling by interacting with the insulin receptor (IR) and IGF-1 receptor. Upon receptor activation, IRS1 is phosphorylated on tyrosine residues, recruiting downstream effectors such as PI3K and Grb2 to activate pathways like PI3K/Akt and Ras/MAPK. IRS1 regulates glucose uptake, metabolism, cell growth, and survival, playing a central role in insulin signaling. It is highly expressed in insulin-sensitive tissues like muscle, liver, and adipose. Dysregulation of IRS1 is associated with insulin resistance, obesity, type 2 diabetes, and cancer, where aberrant signaling promotes proliferation and survival. Knockout studies show growth retardation, metabolic abnormalities, and impaired glucose homeostasis, underscoring its importance in metabolism and cellular signaling.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Insulin Receptor Substrate 1 (IRS1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 31.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro837-Gln1089 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IRS1


dry ice

No


availability

Shipped within 5-7 working days.


alias

IRS1, HIRS-1, insulin receptor substrate 1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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status

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