Mouse Growth Factor Receptor Bound Protein 7 (Grb7) Protein

Este producto es parte de GRB - Growth factor receptor bound protein
Mouse Growth Factor Receptor Bound Protein 7 (Grb7) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein GRB7

proveedor

Abbexa

reference

abx066954

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Growth Factor Receptor Bound Protein 7 (GRB7) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

GRB7 is an adaptor protein that interacts with receptor tyrosine kinases (RTKs) like HER2, VEGFR, and IGF1R, linking them to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and focal adhesion kinase (FAK). GRB7 contains SH2, PH, and proline-rich domains, enabling its localization to membranes and interactions with signaling molecules involved in cell migration, adhesion, and proliferation. GRB7 is highly expressed in cancers, particularly HER2-positive breast cancer, ovarian cancer, and esophageal carcinoma, where it promotes tumor progression, metastasis, and angiogenesis. It also regulates integrin-mediated signaling pathways, playing roles in cell spreading and cytoskeletal organization. GRB7 dysregulation is associated with poor clinical outcomes in cancer patients due to its role in enhancing cell motility and survival. Knockdown studies show reduced tumor cell invasion, highlighting its potential as a therapeutic target in metastatic cancers.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Growth Factor Receptor Bound Protein 7 (Grb7)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 25.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met298-Glu489 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

GRB7


dry ice

No


availability

Shipped within 5-7 working days.


alias

GRB7, entrez:2886, growth factor receptor bound protein 7


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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