Mouse Growth Factor Receptor Bound Protein 2 (Grb2) ELISA Kit

Este producto es parte de GRB - Growth factor receptor bound protein
Mouse Growth Factor Receptor Bound Protein 2 (Grb2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

728€ (96 tests)

Elisa kits for GRB2

proveedor

Abbexa

reference

abx352790

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Growth Factor Receptor Bound Protein 2 (Grb2) ELISA Kit is an ELISA kit against Growth Factor Receptor Bound Protein 2 (Grb2).


Background

GRB2 is an adaptor protein that links receptor tyrosine kinases (RTKs) to downstream signaling pathways, including Ras/MAPK and PI3K/Akt. It consists of one SH2 domain flanked by two SH3 domains, enabling it to interact with phosphorylated tyrosines and proline-rich regions of target proteins. GRB2 primarily binds to proteins like SOS (a Ras GEF), Shc, and PLCγ, facilitating Ras activation and subsequent signaling for cell growth, proliferation, and differentiation. GRB2 is essential for embryonic development, cellular homeostasis, and immune responses. Dysregulation of GRB2 contributes to oncogenesis, particularly in breast, lung, and gastric cancers, where it enhances cell proliferation and survival through constitutive Ras signaling. GRB2 also plays roles in immune cell signaling, particularly T-cell receptor activation and cytokine production. Knockout models demonstrate embryonic lethality, highlighting its critical function in cellular signaling and development.

Características del producto

category

ELISA Kits


immunogen target

Growth Factor Receptor Bound Protein 2 (Grb2)


reactivity

Mouse


test range

0.312 ng/ml - 20 ng/ml


sensitivity

< 0.11 ng/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

GRB2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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