Mouse GRB2 Associated Binding Protein 3 (GAB3) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein GAB3
proveedor
Abbexareference
abx166108Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
GRB2 Associated Binding Protein 3 is a recombinant Mouse protein expressed in E. coli.
Background
GAB3 is an adaptor protein structurally related to GAB1 and GAB2, functioning downstream of receptor tyrosine kinases to activate pathways like PI3K/Akt and MAPK/ERK. It is primarily expressed in hematopoietic cells and immune tissues, where it regulates cell survival, proliferation, and differentiation. GAB3 supports B-cell receptor (BCR) and cytokine-mediated signaling, playing a role in B-cell development and macrophage activation. Its dysregulation is associated with altered immune responses and hematopoietic disorders. GAB3 interacts with SH2-containing proteins to modulate signaling networks involved in immune cell function. Knockout studies suggest a role in regulating inflammatory responses and immune homeostasis, particularly in myeloid and lymphoid lineages.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
GRB2 Associated Binding Protein 3 (GAB3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro142-Asn375 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
GAB3
dry ice
No
availability
Shipped within 5-7 working days.
alias
GAB3,GRB2-associated binder 3
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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