Mouse GRB2 Associated Binding Protein 3 (GAB3) Protein

Este producto es parte de GAB - GRB2 associated binding protein
Mouse GRB2 Associated Binding Protein 3 (GAB3) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein GAB3

proveedor

Abbexa

reference

abx166108

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

GRB2 Associated Binding Protein 3 is a recombinant Mouse protein expressed in E. coli.


Background

GAB3 is an adaptor protein structurally related to GAB1 and GAB2, functioning downstream of receptor tyrosine kinases to activate pathways like PI3K/Akt and MAPK/ERK. It is primarily expressed in hematopoietic cells and immune tissues, where it regulates cell survival, proliferation, and differentiation. GAB3 supports B-cell receptor (BCR) and cytokine-mediated signaling, playing a role in B-cell development and macrophage activation. Its dysregulation is associated with altered immune responses and hematopoietic disorders. GAB3 interacts with SH2-containing proteins to modulate signaling networks involved in immune cell function. Knockout studies suggest a role in regulating inflammatory responses and immune homeostasis, particularly in myeloid and lymphoid lineages.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

GRB2 Associated Binding Protein 3 (GAB3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 29.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro142-Asn375 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

GAB3


dry ice

No


availability

Shipped within 5-7 working days.


alias

GAB3,GRB2-associated binder 3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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