Mouse GRB2 Associated Binding Protein 1 (GAB1) Protein

Este producto es parte de GAB - GRB2 associated binding protein
Mouse GRB2 Associated Binding Protein 1 (GAB1) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein GAB1

proveedor

Abbexa

reference

abx066917

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant GRB2 Associated Binding Protein 1 (GAB1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

GRB2 Associated Binding Protein 1 (GAB1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 28.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro356-His584 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

GAB1


dry ice

No


availability

Shipped within 5-7 working days.


alias

GRB2-associated binder 1,DFNB31


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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