Mouse GRB2 Associated Binding Protein 1 (GAB1) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein GAB1
proveedor
Abbexareference
abx066917Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant GRB2 Associated Binding Protein 1 (GAB1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
GRB2 Associated Binding Protein 1 (GAB1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 28.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro356-His584 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
GAB1
dry ice
No
availability
Shipped within 5-7 working days.
alias
GRB2-associated binder 1,DFNB31
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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