GRB2-Associated-Binding Protein 1 (GAB1) Antibody

Este producto es parte de GAB - GRB2 associated binding protein
Product Graph
383.5€ (100 µl)

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935106861
info@markelab.com
name
GRB2-Associated-Binding Protein 1 (GAB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010862
tested applications
ELISA, WB, IHC, FCM

Description

Grb2-associated binding protein 1 is a member of the IRS-1-like multisubstrate docking protein family. Contains an N-terminal pleckstrin homology (PH) domain and several proline-rich SH3 domain-binding sequences. Mediates branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
GRB2-Associated-Binding Protein 1 (GAB1)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Purified from ascites by Protein G chromatography.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, FCM
Buffer
PBS, containing 0.05% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q13480
Gene ID
2549
OMIM
604439
Alias
GRB2-associated binder 1,DFNB28
Background
Antibody anti-GAB1
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.

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