Mouse GP145-TrkB/GP95-TrkB (TrkB) Protein (Active)
923€ (50 µg)
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935106861
info@markelab.com
name
Mouse GP145-TrkB/GP95-TrkB (TrkB) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692286
tested applications
SDS-PAGE
Description
Mouse TrkB Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse NTRK2 (P15209-2) (Met 1-His 429) was expressed, with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | TrkB |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 46 kDa Sequence Fragment: Met1-His429 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 98% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15209-2 |
| Alias | OBHD,TRKB,DEE58,trk-B,EIEE58,GP145-TrkB,Tropomyosin-related kinase B,TrkB tyrosine kinase,Neurotrophic tyrosine kinase receptor type 2,BDNF/NT-3 growth factors receptor |
| Background | Protein NTRK2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Neurotrophic receptor tyrosine kinase 2 (NTRK2), often referred to as TrkB, interacts specifically with brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5). This receptor is central to processes like neuroplasticity, synaptic strength regulation, and long-term potentiation—mechanisms foundational for cognitive functions such as learning and memory. In addition to its role in brain health, NTRK2 is involved in mood regulation, and aberrations in its signaling pathways are associated with neuropsychiatric disorders, including depression, anxiety, and schizophrenia, emphasizing its role in mental health research and therapeutic interventions.
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