Mouse Glycoprotein 5 (GP5) Protein

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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein GP5
proveedor
Abbexareference
abx066886Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Glycoprotein V, Platelet (GP5) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
Glycoprotein V (GP5) is a key platelet membrane protein that functions as a part of the GPIb-IX-V complex, a receptor system primarily responsible for mediating platelet adhesion during vascular injury. This complex is crucial for the initial steps of platelet plug formation, which is essential in the process of hemostasis, particularly in the high-shear conditions of arterial blood flow. GP5 serves as an accessory component in the complex, complementing the roles of other glycoproteins like GPIbα (GP1BA), GPIbβ (GP1BB), and GPIX (GP9). The GPIb-IX-V complex, including GP5, binds to von Willebrand factor (vWF), which facilitates platelet tethering to the damaged endothelium under conditions of high shear stress. Although GP5 is not the primary binding site for vWF (that role belongs to GP1BA), it contributes to the structural integrity and function of the receptor. GP5 may also interact with other ligands and is thought to regulate the binding activity of the GPIb-IX-V complex.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Glycoprotein 5 (GP5)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.6 kDa Observed MW (SDS-PAGE): 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser246-Glu485 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
GP5
dry ice
No
availability
Shipped within 5-7 working days.
alias
GPV,CD42d,Platelet glycoprotein V,GPV,Glycoprotein 5,CD42d
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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