Mouse Gastrin Releasing Peptide Receptor (GRPR) Protein

Este producto es parte de BB - Bombesin Receptor
Mouse Gastrin Releasing Peptide Receptor (GRPR) Protein

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935106861

info@markelab.com

Precio

234€ (10 µg)

Protein GRPR

proveedor

Abbexa

reference

abx650010

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse GRPR Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

Gastrin Releasing Peptide Receptor (GRPR) is another GPCR within the bombesin-like receptor family that binds gastrin-releasing peptide (GRP). GRPR is expressed in the gastrointestinal tract, pancreas, and the central nervous system (CNS). In the gastrointestinal system, GRPR regulates gastric acid secretion and promotes pancreatic enzyme release, playing a vital role in digestion. It also enhances intestinal smooth muscle contraction, facilitating gastrointestinal motility. In the CNS, GRPR is involved in memory formation and fear conditioning, as it modulates pathways in the amygdala and hippocampus. Additionally, GRPR regulates feeding behavior and satiety, influencing energy homeostasis and food intake. GRPR signaling has garnered significant interest in oncology because it is overexpressed in several cancers, including prostate cancer, small cell lung cancer (SCLC), and gastrointestinal malignancies. Activation of GRPR stimulates tumor growth, cell proliferation, and angiogenesis, making it a key target for cancer diagnostics and therapeutics. Furthermore, GRPR has roles in pruritus (itch sensation), where it modulates spinal cord circuits related to itch and pain perception. Its multifaceted roles in neurobiology, digestion, and oncology position GRPR as a promising candidate for the development of novel treatments for metabolic disorders, neurological conditions, and cancer.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Gastrin Releasing Peptide Receptor (GRPR)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 42.8 kDa Observed MW (SDS-PAGE): 43 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Leu116 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

GRPR


dry ice

No


availability

Shipped within 5-7 working days.


alias

GRPR,BB2 receptor,GRP-R,BB2,GRP-preferring bombesin receptor,Gastrin-releasing peptide receptor,gastrin-releasing peptide receptor,BB2R,BRS2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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status

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clonality

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