Mouse Gastrin Releasing Peptide Receptor (GRPR) Protein

Product specifications

Proteins and Peptides

Gastrin Releasing Peptide Receptor (GRPR)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 42.8 kDa  Observed MW (SDS-PAGE): 43 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Leu116
Tag: N-terminal His tag and GST tag

Recombinant

> 97%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P21729

14829

GRPR,BB2 receptor,GRP-R,BB2,GRP-preferring bombesin receptor,Gastrin-releasing peptide receptor,gastrin-releasing peptide receptor,BB2R,BRS2

Protein GRPR

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Gastrin Releasing Peptide Receptor (GRPR) is another GPCR within the bombesin-like receptor family that binds gastrin-releasing peptide (GRP). GRPR is expressed in the gastrointestinal tract, pancreas, and the central nervous system (CNS). In the gastrointestinal system, GRPR regulates gastric acid secretion and promotes pancreatic enzyme release, playing a vital role in digestion. It also enhances intestinal smooth muscle contraction, facilitating gastrointestinal motility. In the CNS, GRPR is involved in memory formation and fear conditioning, as it modulates pathways in the amygdala and hippocampus. Additionally, GRPR regulates feeding behavior and satiety, influencing energy homeostasis and food intake. GRPR signaling has garnered significant interest in oncology because it is overexpressed in several cancers, including prostate cancer, small cell lung cancer (SCLC), and gastrointestinal malignancies. Activation of GRPR stimulates tumor growth, cell proliferation, and angiogenesis, making it a key target for cancer diagnostics and therapeutics. Furthermore, GRPR has roles in pruritus (itch sensation), where it modulates spinal cord circuits related to itch and pain perception. Its multifaceted roles in neurobiology, digestion, and oncology position GRPR as a promising candidate for the development of novel treatments for metabolic disorders, neurological conditions, and cancer.

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