Mouse Gastrin Releasing Peptide Receptor (GRPR) ELISA Kit
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Description
Mouse Gastrin Releasing Peptide Receptor (GRPR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse GRPR concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Gastrin Releasing Peptide Receptor (GRPR) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P21729 |
| Gene ID | 14829 |
| Alias | GRPR,BB2 receptor,GRP-R,BB2,GRP-preferring bombesin receptor,Gastrin-releasing peptide receptor,gastrin-releasing peptide receptor,BB2R,BRS2 |
| Background | Elisa kits for GRPR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Gastrin Releasing Peptide Receptor (GRPR) is another GPCR within the bombesin-like receptor family that binds gastrin-releasing peptide (GRP). GRPR is expressed in the gastrointestinal tract, pancreas, and the central nervous system (CNS). In the gastrointestinal system, GRPR regulates gastric acid secretion and promotes pancreatic enzyme release, playing a vital role in digestion. It also enhances intestinal smooth muscle contraction, facilitating gastrointestinal motility. In the CNS, GRPR is involved in memory formation and fear conditioning, as it modulates pathways in the amygdala and hippocampus. Additionally, GRPR regulates feeding behavior and satiety, influencing energy homeostasis and food intake. GRPR signaling has garnered significant interest in oncology because it is overexpressed in several cancers, including prostate cancer, small cell lung cancer (SCLC), and gastrointestinal malignancies. Activation of GRPR stimulates tumor growth, cell proliferation, and angiogenesis, making it a key target for cancer diagnostics and therapeutics. Furthermore, GRPR has roles in pruritus (itch sensation), where it modulates spinal cord circuits related to itch and pain perception. Its multifaceted roles in neurobiology, digestion, and oncology position GRPR as a promising candidate for the development of novel treatments for metabolic disorders, neurological conditions, and cancer.
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