Mouse Frizzled Homolog 8 (FZD8) ELISA Kit
715€ (96 tests)
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name
Mouse Frizzled Homolog 8 (FZD8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx518224
tested applications
ELISA
Description
Mouse Frizzled Homolog 8 (FZD8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Frizzled Homolog 8 (FZD8) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Frizzled Homolog 8 (FZD8) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | 7.91 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q61091 |
| Alias | FZD8,FZ-8,hFZ8,frizzled family receptor 8,Fz8 |
| Background | Elisa kits for FZD8 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
FZD8 is a member of the Frizzled receptor family that mediates Wnt signaling, predominantly through the canonical β-catenin-dependent pathway. It is expressed in various tissues, including the brain, heart, and bone, where it regulates cell proliferation, differentiation, and tissue homeostasis. FZD8 plays a significant role in bone formation and osteoblast differentiation, making it essential for skeletal development and regeneration. In cancer, FZD8 is overexpressed in lung, breast, and prostate cancers, where it promotes cell proliferation, survival, and therapy resistance through enhanced Wnt/β-catenin signaling. FZD8 also contributes to angiogenesis and metastasis by regulating endothelial cell function and tumor vascularization. Its role in brain development includes regulating neural differentiation and synaptic plasticity. FZD8 activation triggers downstream pathways like PI3K/Akt and MAPK, driving cellular responses critical for growth and repair. Dysregulation of FZD8 is associated with developmental defects, cancer progression, and bone disorders. Therapeutic targeting of FZD8 to modulate Wnt signaling is being explored to treat cancers and bone-related diseases, highlighting its importance in development and disease.
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